The events of South Park are usually set in the country with the most frequent location being the state of Colorado. However, many episodes also take place in the nation's capital city Washington, D.C.
- Cartman's Confederate army briefly marches through Alabama in "The Red Badge of Gayness".
- Bentonville is the corporate HQ of Wall-Mart, which appears in episode "Something Wall-Mart This Way Comes".
- It is also where the World Wide Recorder Concert took place. Mr. Garrison was born and raised in Arkansas.
- The State and city the of Scottsdale were mentioned in "The Ungroundable" as the place where the Goth Kids sent the leader of the South Park Vampire Society in an effort to stop kids from confusing them with goths.
- The boys take the beggars and hobos from South Park to Santa Monica in episode "Night of the Living Homeless".
- San Francisco was devastated by a smug storm in "Smug Alert!" due to the inhabitants being smug (to the point of smelling their own flatulence) enough to generate an actual atmospheric disturbance.
- The city was once more razed by Cartman and Cthulhu in "Coon vs. Coon & Friends".
- Towelie was sent to rehab in Southern California.
- Aside from Colorado, California is one of the most frequent locations in South Park.
- Butters and Cartman (disguised as A.W.E.S.O.M.-O 4000) visit his Uncle Budd and Aunt Nellie in Los Angeles in "AWESOM-O".
- Marina del Rey harbor in Los Angeles appears in the episodes "Butterballs" and "I Should Have Never Gone Ziplining".
- Colorado is the state in which the fictional town of South Park is located. The state capital is Denver, which has been featured or mentioned quite a few times during the series. Other locations mentioned and visited include Fairplay, Evergreen and Greeley, among others. Fictional towns and cities located in Colorado include North Park, Middle Park and Beaverton.
- South Park is a real life geographical region in Colorado, but there is no actual town referred to as such in real life. The same is true of North Park and Middle Park.
- Sheila's sister and her son Kyle Schwartz live in Connecticut.
- Cartman's Confederate army briefly marches through Florida in "The Red Badge of Gayness", and rides a water slide with that Confederate army.
- Cartman flies to Florida to steal presidential ballots in "Obama Wins!".
- Cartman flies to Florida in "World War Zimmerman", where he is shot in the arm by George Zimmerman.
- Cartman's Confederate army briefly marches through Georgia in "The Red Badge of Gayness".
- Butters and Kenny go to Hawaii, Butters' native land, in "Going Native".
- Cartman's Confederate army marches into Kansas in "The Red Badge of Gayness" and conquers Topeka.
- Cartman goes to Corbin, Kentucky to make a deal with Colonel Sanders about smuggling KFC in Colorado.
- Cartman's Confederate army briefly marches through Missouri in "The Red Badge of Gayness".
- Stan, Kyle, and Cartman go to Las Vegas in "Are You There God? It's Me, Jesus" for New Year's Eve 1999.
- Cartman flies to Nevada to steal presidential ballots in "Obama Wins!".
- New Jersey overtakes half the country in "It's a Jersey Thing".
- Sheila Broflovski was revealed to have been from New Jersey as well as her son Kyle Broflovski being conceived there in "It's a Jersey Thing".
- New York City has appeared in a few episodes.
- The parents got to the Cartoon Central Network to protest Terrance and Phillip in "Death".
- Children from New York heckle the South Park children in "World Wide Recorder Concert".
- Stan, Kyle, and Cartman (with Kenny's soul inside him) travel with Chef to New York to see John Edward in "The Biggest Douche in the Universe".
- Crab People that live under a TV station in New York City, try and turn the worlds men "metrosexual" in order to enslave them in "South Park is Gay!".
- Kyle Broflovski's cousin Kyle Schwartz is from New York.
- In "Pandemic 2: The Startling", New York is attacked by guinea pigs.
- In Broadway Bro Down, Randy and Sharon Marsh went to New York City to see Broadway shows.
- Cartman flies to North Carolina to steal presidential ballots in "Obama Wins!".
- Cartman flies to Ohio to steal presidential ballots in "Obama Wins!".
- Philadelphia and the Independence Hall are located in this state, and "Sexual Healing" partially takes part in this state.
- Cartman's Confederate army marches into South Carolina in "The Red Badge of Gayness" to take Fort Sumter. Stan, Kyle, and Marvin Marsh, along with U.S. National Guard soldiers, arrive to confront them, only to be outnumbered when the entire state joins Cartman's army.
- Cartman's Confederate army marches into Tennessee in "The Red Badge of Gayness" and conquers Chattanooga. Stan, Kyle, and Marvin Marsh arrive, too, but are unable to stop them. Kenny, who is part of Cartman's army, is killed in the city by U.S. soldiers.
- Cartman joins the U.S. Border Patrol in "The Last of the Meheecans" to prevent Butters from returning to the United States from Mexico.
- Throughout the Imaginationland trilogy, Cartman, Stan, and Kyle go to the Pentagon.
- In the episode "How to Eat with Your Butt", Martha and Stephen Thompson, the couple with Reverse Polarity Syndrome, are from Wisconsin.
- In "Summer Sucks", Mr. Hat runs away to Green Bay, Wisconsin where he meets Brett Favre in the locker room of the Green Bay Packers.
- Washington, D.C., the nation's capital, has appeared in several episodes.
- Liane Cartman goes to the White House and has sex with President Bill Clinton in "Cartman's Mom is Still a Dirty Slut" to try and legalize fortieth trimester abortions.
- President Clinton informs the nation about increasing Japanese military presence in the United States in "Chinpokomon".
- Cartman's Confederate army marches into Washington, D.C., in "The Red Badge of Gayness" to negotiate peace terms with President Clinton. Stan and Kyle intervene and Cartman's Confederate rebellion ends in failure.
- David Blaine's cult goes to Washington, D.C., to commit mass suicide in the Lincoln Memorial Reflecting Pool. Stan, along with the Super Best Friends save Kyle and Cartman in "Super Best Friends".
- President George W. Bush is informed that the boys' ladder to Heaven in "A Ladder to Heaven".
- Josh Myers is seen preparing to toilet paper the White House in "Toilet Paper".
- Kenny's feeding tube in "Best Friends Forever".
- President Bush delivers a press conference at the White House about Family Guy's plans to air a Muhammad episode in "Cartoon Wars Part II".
- Stan and Kyle end up in Washington, D.C., in "Mystery of the Urinal Deuce" and are brought to the White House, where they are told by President Bush about the government's involvement in 9/11, which later turns out to have been a lie to make the government appear all-powerful.
- Randy Marsh goes to the Washington, D.C., where he is to accept his award for the largest piece of fecal matter, only to be interrupted and upstaged by a video of Bono.
- Stan, Kyle, and Cartman end up at the Pentagon during the Imaginationland trilogy, and Kyle and Cartman eventually end up at the Washington, D.C., Memorial Hospital, after Kyle is attacked by ManBearPig.
- Barack Obama, John McCain, Michelle Obama, and Sarah Palin all partake in a jewel heist, stealing the Hope Diamond from the Smithsonian Institute in "About Last Night...".
- The government seeks to deal with sexual addiction in "Sexual Healing" and President Obama calls for the outbreak, traced back to Independence Hall, to be eliminated.
- President Obama announces, from the White House, the imminent destruction of the country in "Funnybot".
- Duck President appears in "Ass Burgers", signing a bill. He is later removed from the Oval Office and President Obama returns.
- President Obama receives a phone call at the White House from General Tso, regarding his election victory in "Obama Wins!".