The name Uncle may refer to any of the characters listed below.
- Uncle Budd - Butters Stotch's uncle, who may have molested him.
- "Uncle Fucka" - Song sung by Terrance and Phillip at the end of Asses of Fire in South Park: Bigger, Longer & Uncut.
- Uncle Sam - Personification of the United States government.
- Uncle Stinky - Uncle to Eric Cartman seen prominently in "Merry Christmas Charlie Manson!".