The name Thomas may refer to:
- Thomas - A boy who suffers from Tourette's Syndrome.
- Thomas (Charlotte's Father) - Charlotte's Father
- Thomas Tucker - Craig Tucker's Father
- Thomas Jefferson - The third President of the United States.
- Thomas McElroy - Chef's Father
- Tom - The father of Kevin, the boy who was frozen in ice and thawed out in "Summer Sucks".
- Tom Foley - A dentist who plays a prominent role in "The Tooth Fairy Tats 2000".
- Tom Johannsen - An ice cream shop owner wrongly accused of being the serial killer in "Cartman's Incredible Gift".
- Tom Pusslicker - A newscaster for Channel 4 News who frequently reads reports about Hillary Clinton's ass.
- Tom Thompson - A newscaster for Channel 4 News who later replaced Tom Pusslicker.
- Tom Cruise - A famous actor who appears in "Trapped in the Closet" and "200"/"201".
- Tom Shane - The president and spokesperson of the Shane Company, who appears in "Guitar Queer-O".
- Tommy ("Medicinal Fried Chicken") - KFC dealer under Billy Miller who appeared in "Medicinal Fried Chicken".
- Tommy Edwards - Boy whose crush is revealed by Wikileaks in "Bass to Mouth".
- Tommy Fritz - Boy auditioning at the Cheesy Poofs Talent Ship in "Roger Ebert Should Lay off the Fatty Foods".
- Tom "Bat Dad" Nelson- A trash talking parent who appears in "The Losing Edge".
- Tommy Turner - Boy who sanded his face off with a belt sander in "Tweek vs. Craig".