Stan Marsh and Kyle Broflovski play this song on Guitar Hero, after Eric Cartman ridicules Randy Marsh for playing a real guitar. Craig Tucker tells Randy he would rather see Stan and Kyle play the game instead.
Later, Thad Jarvis and Stan are practicing and cannot decide on a song to play. Stan wants to play "Surrender", but Thad calls the song 'bubblegum crap'. This causes an argument prompting Thad to quit the Guitar Hero group.