South Park Guide to Life is a small book featuring quotes from iconic South Park scenes, presented as life advice. Each of the book's 141 pages features a scene, with a matching quote, from episodes in Seasons One thru Twelve.
South Park Guide to Life begins with a table of contents, set to Cartman's living room. The book then features a foreword by Brian Boitano, followed by a series of chapters broken down by general topic. The book concludes with the boys shown having learned something today.