O.J Simpson appeared in the episode, "Butters' Very Own Episode", in which he joined Butters' parents in searching for "Some Puerto Rican Guy", who is allegedly responsible for Butters' disappearance and Nicole Brown Simpson's death. He appeared in "200" at Tom Cruise's house, despite being in prison for an unrelated crime when "200" aired. O.J. is also referenced many times in the episode "Chef Aid". He also appeared in a The Simpsons Sketch parodying South Park.
O.J. wears a tan, golf shirt, a blue coat, and gray pants. He also has an abnormally shaped nose.
O.J. was in a "club" for people who have had their loved ones supposedly killed/kidnapped by Some Puerto Rican Guy. Throughout "Butters' Very Own Episode", it is heavily implied that the "club" is, in reality, a group of people who got away with murder. It is assumed they all share a friendship.