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Nanny Skexis was seen during the Nanny 911 parody montage, as one of the nannies sent to discipline children who are out of control. Liane Cartman sees this program as an inspiration to get Eric Cartman to behave.
A Skexis is seen again in "Imaginationland, Episode II" as one of the evil characters that broke through the blown up barrier to attack everyone's imagination.
Another Skexis is seen again in "Imaginationland, Episode III" in the final battle.