The Mackey Residence is Mr. Mackey's home. The outside briefly appeared in the Season Two episode, "Ike's Wee Wee" but the rest of the house was shown in the Season Three episode, "Two Guys Naked in a Hot Tub".
Mr. Mackey's house is built just like every other house in South Park. The house is colored a red-brownish color. He has three connected mailboxes outside, odd since most other houses in South Park don't have one. His garden has a Hot Tub on the decking.
Mr. Mackey's house has a front room on the first floor large enough to host parties in. On the second floor his bedroom and presumably a bathroom exist. His basement is also shown, there's likely more than one room as the one shown has a door leading into it rather than stairs.