- For a list of male fourth graders, see: List of Male 4th Graders.
- Main article: Annie
Annie first appeared in "Butters' Bottom Bitch", where she joined Butters' kissing company. She has not had any speaking roles.
- Main article: Annie Knitts
Annie Knitts made her first appearance in "Cartman Gets an Anal Probe". She is considered one of the popular girls in South Park Elementary. She is commonly seen with Wendy, Bebe, Red, Heidi, Milly, Lola, Esther, Sally, and in later episodes, Blonde Girl.
- Main article: Bebe Stevens
- Main article: Beth
- Main article: Blonde Girl
- Main article: Emily
Emily first appeared in "Tonsil Trouble". In "Bass to Mouth" it was revealed that her mother was in rehab. She appears to be best friends with Tammy Nelson. So far, "Bass to Mouth" is the only episode she played a role in.
- Main article: Esther
Esther made her first appearance in "Rainforest Shmainforest". In "Rainforest Shmainforest", she was a member of the Getting Gay With Kids choir. She is considered one of the popular girls. Despite her many appearances, she has not, so far, played a major role in any episode. She is usually seen in the background, talking to Heidi Turner.
- Main article: Molly
Molly is a background character that played a minor role in "T.M.I.". Her appearance in "T.M.I." is, so far, her only appearance where she does not have black hair. She is, currently, the only known student to wear a vest.
Girl with Brown Coat
- Main article: Girl with Brown Coat
This girl, who is so far unnamed, was a background character but also played a minor role in "T.M.I.". She hasn't been seen since. She is most notable for having a hair clip which resembles a cherry.
Girl with Pink Sweater
- Main article: Girl with Pink Sweater
Girl with Pink Sweater, who is so far unnamed, is a background character. She first appeared in "The List". She took Pip Pirrup's seat after he was killed by Mecha-Streisand in "201". She is most notable for being one of four fourth graders to wear a skirt, the others being Blonde Girl, Sally Darson, and Kelly Gardner.
- Main article: Heidi Turner
Heidi's first appearance was in "Rainforest Shmainforest". She is one of the popular girls at "South Park Elementary". Heidi's first major role was in "Marjorine", where she hosted a sleepover with Wendy, Bebe, Emily, Tammy Nelson, Milly, Red, Esther, and Kal. As of Season Twenty, she is Eric Cartman's girlfriend.
- Main article: Jenny Simon
Jenny Simon made her first appearance in "The List", as a co-head of the list-making committee. In "Bass to Mouth" she, after being fooled by Cartman into eating a laxative-laced cupcake, defecated in her pants in front of Mr. Garrison's class. That incident led her to attempt suicide by jumping off the school roof, however, she survived with only a fractured pelvis.
- Main article: Jessie
Jessie first appeared in "Stupid Spoiled Whore Video Playset", where she participated in the "Stupid Spoiled Whore" fad as well as playing with the "Stupid Spoiled Whore Video Playset. She, along with Kal, seem to be Wendy's "backup" friends, with Wendy only going to them when the other girls were acting strangely.
- Main article: Kal
- Main article: Kelly Pinkerton-Tinfurter
This girl, whose name was revealed in "Stupid Spoiled Whore Video Playset", isn't seen commonly as a background character, however, she does rarely appear in the background as well as large crowd scenes.
- Main article: Kelly Rutherford-Menskin
This girl, whose name was revealed in "Stupid Spoiled Whore Video Playset", isn't seen commonly as a background character, usually only appearing in large crowd scenes.
- Main article: Lizzy
Lizzy made her first appearance in "Hooked on Monkey Phonics". She played a major role in "Cartman's Silly Hate Crime 2000", where she taunted, along with the other girls, taunted the boys and challenged them to a sledding race.
- Main article: Lola
- Main article: Mandy
- Main article: Meagan Ridley
- Main article: Milly
Milly made her first appearance in "Rainforest Shmainforest", as part of the Getting Gay With Kids choir. She is one of the popular girls. She is commonly at a lunch table with all of the other popular girls.
- Main article: Nancy
Nancy made her first and only appearance in "Up the Down Steroid". She was Jimmy's girlfriend. Jimmy later beat her up, however, we can assume they are still on good terms, as she was seen rooting for Jimmy at the Special Olympics.
- Main article: Nelly
Nelly made her first appearance in "Free Willzyx". She played a minor role in "The List", where she was revealed as the list keeper for the List Making Committee. She later beat Butters up, after the failure of Operation Cannot Possibly Fail.
- Main article: Nichole Daniels
Nichole was first seen in "Cartman Finds Love", where she was seen in a relationship with Token, which was heavily encouraged by Eric Cartman. After seeing a racial remark, which she thought was from Token, she broke up with him. After realizing that it was Cartman who made the remark, the two reunited and resumed their relationship.Earlier in the same episode, she confessed to having a crush on Kyle.
- Main article: Patty Nelson
- Main article: Red
Red made her first appearance in "Cartman Gets an Anal Probe". She is one of the popular girls at South Park Elementary. She is debatably the third most prominent female fourth grader, behind Wendy and Bebe.
She has had multiple names but Red seems to have stuck. She has been called Bertha, Rebecca, and Red
- Main article: Sally Darson
- Main article: Sally Turner
- Main article: Samantha Dunskin
- Main article: Shauna
- Main article: Tammy Nelson
- Main article: Wendy Testaburger
Wendy made her first appearance in "The Spirit of Christmas (Jesus vs. Santa)". She is the leader of the popular girls "clique". She is also Stan's girlfriend. She is shown to be Bebe's best friend. She seems to have extreme jealousy issues. When she felt that her relationship with Stan was threatened by Ms. Ellen, she had her shot into the center of the sun. Another incident of her jealousy can be shown in "Bebe's Boobs Destroy Society", where, after Bebe starts developing breasts and the boys start paying much more attention to her, she turns on Bebe and begins gossiping about her, along with the rest of the popular girls.