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Legion of Doom was formed by Christopher Reeve with the mission to stop Hack-Man from getting the law passed to stop his eating of baby fetuses. These fetus's stem-cells keep Christopher fit by reversing the effects of his paralysis.
- Main article: Christopher Reeve
Christopher Reeve is an actor and activist in stem-cell research for persons with physical disabilities. He is also the founder of the Legion of Doom in the episode, "Krazy Kripples".
Osama bin Laden
- Main article: Osama bin Laden
- Main article: Saddam Hussein
Saddam Hussein is the former dictator of Iraq and a former resident of Hell. He is a current resident of Heaven. He was last seen in the episode, "It's Christmas in Canada", where he was the deposed Prime Minister of Canada.
- Main article: Kim Jong-il
Kim Jong-il is the former leader of North Korea, he was previously seen in the feature film Team America: World Police.
- Main article: David Blaine
Professor Chaos and General Disarray
- Main article: Professor Chaos
Butters Stotch's alter-ego Professor Chaos and his sidekick General Disarray were initially members of the Legion of Doom, however, they quit after realizing how sensitive the subject matter was, claiming that they should "stay out of this one." He was previously seen in the episode "My Future Self n' Me".
Dr. Victor von Doom is a comic-book villain created by Stan Lee.
Dr. Octopus is a major antagonist in the Spider-Man series of comics.