Timmy and Jimmy start a club for cripples. Meanwhile, Christopher Reeve comes to town to promote stem cell research.
When Jimmy's comedy act is snubbed by the townspeople in favor of an inspirational talk by Christopher Reeve. Timmy and Jimmy form a club for genuine cripples, born that way, not wannabe posers like he says Christopher Reeve is. Timmy and Jimmy start their own club, dubbed "the Crips" unaware of the notorious street gang that shares the same name. Eventually Timmy and Jimmy find out about the Crips, and under the belief that it is a group of disabled people like themselves, the boys want to join the gang. When they tell the four main characters - Stan, Kyle, Cartman, and Kenny of their intentions, Stan suggests that "maybe they should just stay out of this one". The other three agree, and leave immediately.
The Crips leader in Denver tells the boys to "pop some punk ass Bloods". The boys do not know that the term actually means kill some Bloods, so they wander the town to find the Bloods while believing that they are supposed to buy treats for them. They find a group of Bloods at a Convenient Store called "Ribs 'n' Gas". While walking across the street a trucker swerves to avoid hitting Jimmy and Timmy but winds up blowing up the whole gas station, killing all thirteen Bloods inside. The Crips leader then welcomes Jimmy ("Four Legs") and Timmy ("Roller"), stating "You're not just in it, you the baddest mofo Crips in town", because they killed thirteen Bloods in one night (a new Crips gang record) and brought back marshmallows and ginger ale.
Jimmy's parents ask Jimmy if he is in a gang, which he admits to. It is revealed at this point that the Valmers had made fun of handicapped kids at High School and believed that God had made Jimmy handicapped to punish them, so they naturally believe that this is part of a punishment. The next night the Bloods gang members commit a drive-by shooting on Jimmy's house as retaliation for the killing of the thirteen Bloods. In order to prevent further reprisals, Jimmy decides to call a meeting at the local recreation center between the two gangs, and lock themselves in for the evening until they can sort out their differences. Expectedly, both gangs initially act hostile to one another, but Jimmy manages to convince them to sort out their differences by saying "Come on!" repeatedly and manages to bring the two gangs together, as they all then participate in various games and activities inside the recreation center as friends.
Meanwhile, Christopher Reeve campaigns for stem cell research for the handicapped. By cracking open fetuses and sucking out their juices, he soon regains mobility, and even superpowers like the character he portrayed, Superman. He eventually takes on the role of a supervillain, and is opposed by his archnemesis, Gene Hackman (the actor who portrayed supervillain Lex Luthor, Superman's archnemesis, whom Reeve refers to as Hack Man). This causes one reporter to comment that "if irony were made of strawberries, we'd all be drinking a lot of smoothies right now." Reeve continues to use stem cells even after he is healed and becomes addicted to power, and eventually puts together a Legion of Doom made up of villains from the comic and South Park universes. (Professor Chaos tells General Disarray that they should "stay out of this one.", much like the boys did in the A-plot) At the end Hackman manages to get a law passed to end Reeve's "fetus-sucking days," and traps Reeve in the Phantom Zone.
The episode ends with the four boys — having watched all the events, remarking that they were "so glad they stayed out of that one."