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- "Guitar Queer-O" - A can of Dr. Pep-er can be seen in the living room while the boys play Guitar Hero.
- "The Ungroundable" - Butters brings the vampires a case of Dr. Pep-er as an offering before his initiation.
- "Sexual Healing" - Eric Cartman is seen with the can of the drink (amongst other snacks) while playing Tiger Woods PGA Tour 2011 with Stan Marsh.
- "Insheeption" - When Stan is reading a note from Wendy, a can of Dr. Pep-er is highly visible in front of Kyle.
- "Ass Burgers" Wendy has a can of it during her picnic with Stan in the "Landslide" segment of the episode.
- "The Poor Kid" - The Weatherheads and their army of foster children drink only Dr. Pep-er and Diet Dr. Pep-er, as it is an "agnostic beverage" in that nobody knows exactly what it tastes of.
- "Sarcastaball" - Butters Stotch was seen drinking the beverage while watching football with the boys and Randy Marsh.