Ms. Garrison gets dumped again, after complaining about men she is told about lesbianism. Unfortunately, the lesbian bar Les Bos has been bought by Persians.
Ms. Garrison enters her classroom as her students are settling in, and vents some anger she had built up for a bad blind date she had the night before. She yells and insults the students, just before assigning their homework, which will be to read 'The Old Man and the Sea,' and to write an essay about it over the weekend and have it finished by Monday. Stan, Kyle, Kenny and Cartman are not happy about the fact they will have to spend their whole weekend doing homework, but Cartman has a plan that will fix their problem. Cartman brings the three others to the back of a truck rental place, where a group of Mexicans are located. Cartman tells them to read the book, and write four different essays for them, and the boy go off to enjoy their weekend.
Meanwhile, Mrs. Garrison goes to the all-female gym Curves to work out, and still release some built up anger. As she curses out men on the treadmill, a woman named Allison gets onto the treadmill beside her, and the two strike up a conversation, sharing a common dislike of men. Allison then invites Mrs. Garrison down to the all female bar, Les Bos. It doesn't take Mrs. Garrison to long to realize though that Les Bos is a Lesbian Bar, and runs off to the bathroom horrified. Allison follows her, and the talk the two have makes Mrs. Garrison wonder about her sexuality, and the two end up kissing, and then having sex all night.
The four boys return on Monday morning to the Mexicans out back by the Truck Rental place to pick up their essay from the Mexicans. The Mexicans read the books, but did not write essays. Instead, they wrote to their esses (Friends). The boys blame Cartman for the misunderstanding, and they find out at school everyone else did their book reports. They are surprised though when Mrs. Garrison gives them more time for their report. She then tells her students that she is gay, to which Stan replies "Again?" The class likes this newfound personality in their teacher, and encourages her in her choice.
That night Mrs. Garrison returns to Les Bos, a lot more confidently then the night before. She makes small talk with people, but then gets into a fight with another lesbian, which is interrupted when a woman comes in and tells them some bad news. Les Bos is being closed down for good, because it is being bought out by Persians. Herbert Garrison is not happy about this, and refuses to leave. She brings the lesbians to Mayor McDaniels to try and save Les Bos, but the mayor sends them away from her office. Mrs. Garrison does not give up though, and encourages her fellow lesbians not to give up hope. A Persian representative visits Les Bos to talk to the lesbians, to try and reason with them, but has to deal with Mrs. Garrison. After meeting heavy resistance from the woman at the bar, the Persian says, "Look, we don't have to offer you anything. So, I don't know why you’re being so difficult, this is crazy!"
Mrs. Garrison responds with, "No. This isn't crazy. THIS IS LES BOS!" (A parody of a famous line from the movie 300) and then kicks the Persian representative in the balls. Because of this, the fact the lesbians were refusing to give up their bar hit the news, and lesbians everywhere began to support their fight. The Persian representative returned to his co-workers, and told them of how the 30 Lesbians were refusing to give up the bar, and so called more Persians for help. The Persians prepared for an attack, and charged Les Bos, and the Lesbians that stood outside. The fight that followed only involved pushing and shoving back and forth, and in the end the Persian grew tired and retreated. The lesbians celebrated their victory, as the Persian returned to their HQ, where they confronted their boss, Raluf Xerxes. Xerxes gets angry, and decides he must confront the Lesbians himself.
At Les Bos, Mrs. Garrison comes up with a plan to send in Mexicans to Club Persh, the Persian base, and dig up any information they can to use against the Persians. A full day passed, and the lesbians were getting tired. To keep them energetic, Mrs. Garrison made coffee, and after that the Mexicans came back with some valuable information on Xerxes. When Xerxes arrives and confronts Mrs. Garrison, who reveals that they know Xerxes is actually a woman, and threaten to expose her secret. When Mrs. Garrison tells her that lesbians accept woman no matter who they are or how they look, Xerxes is delighted, and ends up having sex with Mrs. Garrison. Xerxes then decides to let Les Bos stay, and the lesbians celebrate.
When Allison question Mrs. Garrison why she isn't teaching right now, she tells her that the school hired someone to fill in for her, which turn out to be the Mexicans who are teaching the class Math, and Kyle says he is actually learning something for once.