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Artemis Clyde Frog was one of Eric Cartman's stuffed animals. It was known as Eric's most favorite toy, as evidenced in "Die Hippie, Die", where he says a tearful farewell to Clyde Frog before he goes on a dangerous mission. In some episodes, when Eric was alone, he asked Clyde Frog for advice, and he seems to have seen the stuffed animal as a friend as seen in "Die Hippie, Die". Clyde Frog is based upon a character of the same name from a children's educational program from the late 1970s called "The Clyde Frog Show".
In the episode "The Wacky Molestation Adventure" he is seen in Mayor Cartman's office, and in the episode "The Jeffersons", in the toy grab machine at Mr. Jefferson's house you can see Clyde frog inside it in many scenes. Clyde Frog was torn apart in "Tonsil Trouble", when an enraged Kyle ripped Clyde's head off as payback when finding out that Cartman had infected him with HIV, but Clyde Frog makes an appearance in-tact in the Season Thirteen episode "Dances With Smurfs". In Season Fourteen DVD, Clyde Frog was in a deleted scene for "201". He is also seen in the basement in "The Last of the Meheecans".
He ends up dying in the episode "1%". Cartman referred to him as "Artemus Clyde Frog" while playing Wild Wild West, most likely in reference to the character Artemus Gordon from the movie.
In South Park Let's Go Tower Defense Play!, Clyde Frog is the trophy given to the player if they get a Silver medal.
Clyde Frog "died" in the Season Fifteen episode "1%". He was murdered at the hands of Cartman, who pretended it was Polly Prissypants, after he was told to grow up and "killed" all of his stuffed dolls in a dramatic way. He was the first out of Cartman's toys to "die".
Clyde Frog is an anthropomorphic, stuffed frog. He has a green body, a pink mouth, and a red tongue. In "Cartman Joins NAMBLA", and in "Cartman's Mom is a Dirty Slut", Clyde Frog's body was colored differently, and was more gray than green.