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In "Chickenpox," the chickenpox virus spreads throughout South Park and Shelly Marsh is infected. Sharon takes her to see Dr. Doctor for treatment; however, he recommends children should come into contact with chickenpox at a young age, as the virus is more dangerous if a person is infected at an older age.
Upon hearing this advice, the boys' parents scheme to get their children infected, by having them play with Kenny, who also is sick with chickenpox. Kyle is the only child not affected by the virus, and appears to be immune to it. His mother Sheila sends him to Kenny's house, in hopes of him becoming infected.